Animal studies are a vital part of scientific endeavour, particularly for clinical trials, but it is vital that the information gleaned from them is robust and that animals are not being put through unnecessary procedures. Researchers have been doing a systematic review of trials and assessed them for their statistical robustness.
The research, published in PLoS Biology, looks at issues such as randomisation and blinding which increase rigour and reduce the risk of bias.
Two of the authors came along to the Science Media Centre to discuss:
Roundup comments accompanied this briefing.
Dr Emily Sena, Centre for Clinical Brain Sciences, University of Edinburgh
Prof. Malcolm Macleod, Professor of Neurology and Translational Neuroscience, University of Edinburgh