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expert reaction to study looking at the gene HLA-DRB1*04:01 in people with asymptomatic SARS-CoV-2 infection or severe COVID-19 disease

A study published in the HLA journal looks at the influence of the HLA genotype on the severity of COVID-19 infection.


Prof Martin Hibberd, Professor of Emerging Infectious Disease, London School of Hygiene & Tropical Medicine, said:

“While this paper raises some interesting ideas, the findings need to be replicated before firm conclusions can be made.  For this type of investigation, typically thousands of subjects need to be investigated to reach robust significance levels.  There have now been a number of studies of sufficient scale, that have been able to show good evidence of gene involvement such as blood group type, but not yet HLA involvement.  I think for these novel findings we need more evidence, which could be achieved by replication of the study findings in larger cohorts.”



The influence of HLA genotype on the severity of COVID-19 infection’ by David J. Langton et al. was published in the HLA journal.

DOI: 10.1111/tan.14284



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