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Ketamine and depression

Severe depression is the number one psychological disorder in the UK and yet 30% of patients do not respond to … read more

the facts about antidepressants

Antidepressants are a constant source of controversy. Concerns are raised that these drugs are not safe, that the side-effects are being overlooked, that they are being over-prescribed and are part of a trend of over-medicalisation. read more

expert reaction to genetic associations for major depressive disorder

A group of researchers have attempted to find genetic markers of major depressive disorder by using samples from patients with self-reported diagnosis. Publishing in the journal Nature Genetics the team report a number of markers which they say are associated with self-reporting of clinical diagnosis or treatment for depression. read more

expert reaction to behavioural activation therapy for depression

A comparison between cognitive behavioural therapy (CBT) and behavioural activation (BA) for the treatment of depression is made in a study published in The Lancet journal. The authors report that the two treatments are equally effective at treating depression in adults and that BA can be delivered by junior mental health workers at a lower cost. read more

expert reaction to antidepressant use in children and teens

While major depressive disorder is one of the most common mental disorders in children and adolescents, the use of pharmacological intervention to treat it remains controversial. A meta-analysis published in the Lancet reported that of 14 different antidepressants trialled in children, only one was significantly more effective than a placebo. read more

Psilocybin – an option for treatment-resistant depression?

Psilocybin, the active component of magic mushrooms, is being seriously considered as a therapy for people with treatment-resistant depression. One in five people suffer from depression at some point in their lives – a significant proportion of whom cannot be helped with any current psychotherapy or drugs. In 2012 researchers published a paper which used fMRI scans to show the effects of psilocybin on the brain. A related paper, published at the same time, suggested that psilocybin could be a useful tool in psychotherapy. The researchers have now gone on to test the safety of psilocybin in a small group of patients with treatment-resistant depression. They are publishing their new findings, funded by the Medical Research Council, in The Lancet Psychiatry. read more

expert reaction to psilocybin and treatment-resistant depression

Psilocybin, the active component of magic mushrooms, is being seriously considered as a therapy for people with treatment-resistant depression. Publishing in The Lancet Psychiatry journal a group researchers have now gone on to test the safety of psilocybin in a small group of patients with treatment-resistant depression. read more

expert reaction to study looking at testosterone treatment in older men with low testosterone

A group of scientists have published their work in the New England Journal of Medicine where they attempted to analyse the effect of raising testosterone levels in older men over the age of 65 with very low testosterone levels, and reported that this had a moderate benefit regarding sexual function and some benefit with regard to mood and depressive symptoms, but not with vitality. read more

expert reaction to antidepressant use and suicidality

The effect of specific types of antidepressants on mortality, suicide and aggressive behaviours is the subject of a paper published in The BMJ in which the authors report an increased risk of suicidality and aggression in children and adolescents taking those dru read more

expert reaction to antidepressant paroxetine and birth defects

Publishing in the British Journal of Clinical Pharmacology a group of scientists have investigated the effects of taking a specific antidepressant while pregnant on birth defects. In the meta-analysis they report that using paroxetine in the first trimester of pregnancy was associated with an increased risk of cardiac-specific as well as general birth defects. read more

expert reaction to MBRRACE-UK report citing mental health as main cause of perinatal death

Whilst the number of direct pregnancy-related deaths has been steadily falling, the same cannot be said for indirect deaths linked to mental health. In fact almost a quarter of women who died due to indirect effects were due to mental health reasons and experts argue that these deaths were often unnecessary. Using data from the Confidential Enquiry into Maternal Deaths (MBRRACE-UK), experts have assessed pregnancy-related deaths from 2009-2013 including reviews of more than 100 women who committed suicide during pregnancy or in the year after giving birth. read more

perinatal depression and suicide

Whilst the number of direct pregnancy-related deaths has been steadily falling, the same cannot be said for indirect deaths linked to mental health. In fact almost a quarter of women who died due to indirect effects were due to mental health reasons and experts argue that these deaths were often unnecessary. Using data from the Confidential Enquiry into Maternal Deaths (MBRRACE-UK), experts have assessed pregnancy-related deaths from 2009-2013 including reviews of more than 100 women who committed suicide during pregnancy or in the year after giving birth. read more

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