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alzheimer’s treatments – what now?

Following the failure of the recent solanezumab trial the question now is where does Alzheimer’s research go from here? We have brought together four top experts to discuss:

Is the solanezumab trial a complete failure? Can we learn anything from it?

Is this the end for the amyloid hypothesis? Could we be going about this all wrong? Is Tau the answer?

What other drugs are in the pipeline? Do the solanezumab results lower our hopes for their success?

Are there other non-drug therapies on the horizon that might offer success?

Will we not progress until we get better at detecting and diagnosing this disease?

Do we think we will ever find a treatment? Is our only hope to reduce lifestyle risks as much as possible? read more

expert reaction to mouse study of gene therapy for Alzheimer’s disease

A group of scientists have described their use of a specific gene therapy to treat Alzheimer’s disease in a mouse model. Publishing in the journal Proceedings of the National Academy of Sciences the scientists report that the upregulation of the PGC-1α gene brought about reduced biological markers of the disease and improved function in the mice. read more

expert reaction to amyloid therapy for Alzheimer’s

An antibody therapy for the treatment of Alzheimer’s disease has been described in a paper published in the journal Nature in which the authors report its use in animals and a small number of patients where the treatment was able to reduce amyloid plaques which are thought to contribute to the disease. read more

expert reaction to UK dementia rates

In a new study, published in Nature Communications, researchers compared the actual number of dementia cases in the UK to earlier decades and previous predictions. They report a 20% drop in incidence of dementia between their two samples (1989-1994, 2008-2011) which they attribute mainly to a reduction in men. read more

expert reaction to IL-33 protein for dementia in mice

Finding the causes of, and treatments for, Alzheimer’s disease is important to reduce the burden of ageing, and the authors of a paper published in the journal PNAS report the use as a therapy of a particular protein which is involved in inflammation. read more

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