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expert reaction to study looking at LDL cholesterol levels and heart events in people that have heart disease and are taking statins

An observational study published in JAMA Internal Medicine reported that, in patients with pre-existing ischemic heart disease, those with ‘moderate’ levels of LDL (bad) cholesterol had lower risk of adverse cardiac outcomes when using statins compared to those with ‘high’ levels of LDL cholesterol, but no additional benefit was seen for those with levels defined as ‘low’. read more

expert reaction to study investigating the effect of cholinesterase inhibitors on delaying the symptoms of Alzheimer’s disease and nursing home placement

Publishing in The Lancet Neurology journal, researchers have published their work looking for current therapies that may have an impact on Alzheimer’s. They report a secondary analysis of the DOMINO trial (announced in 2012)which suggests an off-patent drug may be able to delay the need for Alzheimer’s patients to enter nursing homes. read more

expert reaction to final NICE guidance on cardiovascular disease and statin use

NICE published its final updated guidance on starting preventive treatment of cardiovascular disease (CVD) advising that the threshold for starting treatment should be halved from a 20% risk of developing CVD over 10 years to a 10% risk, and that once lifestyle factors have been addressed high intensity statin therapy should be offered. read more

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