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mitochondrial DNA

IVF techniques to replace the faulty mitochondria, which have their own DNA, of patients with certain genetic disorders have been developed in recent years. 

 

Scientific and ethical reviews and public consultations have been carried out, with a view to changing UK regulations and making the techniques available to patients. Find all SMC work on the subject here.

expert reaction to study looking at mitochondrial DNA and the nuclear genome

Research published in Science shows that mitochondria interact with cell nucleus’ in ways previously unseen in humans. Matching mitochondrial DNA … read more

interplay between mitochondria and nucleus may have implications for mitochondrial donation treatment

Scientists at the University of Cambridge have identified new ways in which mitochondria, the ‘batteries’ that produce our energy, interact … read more

expert reaction to a correspondence piece “mitochondrial donation — which women could benefit?”

Reactions to a piece published in NEJM which discusses which women stand to benefit from mitochondrial donation.    Dr Hansong … read more

expert reaction to media reports that a US scientist has used mitochondrial replacement therapy to make embryos for four women who are carriers of mitochondrial disease

Expert reaction to media reports that a US scientist talking at a public meeting at Harvard University has said he … read more

expert reaction to news of birth of baby through mitochondrial DNA transfer for infertility in greece

Reactions to news of the birth of a baby through mitochondrial DNA transfer in Greece. A spokesperson for the Human … read more

expert reaction to news that doctors at Newcastle Fertility Centre are first in UK granted permission to use mitochondrial replacement therapy

The HFEA has granted doctors at Newcastle Fertility Centre permission to perform mitochondrial replacement therapy on two women who are at risk of passing on mitochondrial disease to their offspring.  read more

expert reaction to the Charlie Gard case

The parents of terminally-ill baby Charlie Gard have ended their legal challenge to take him to the US for experimental treatment.
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Why we need scientists on Charlie Gard

This is a guest post by Tom Sheldon, Senior Press Manager at the SMC.   There can’t be many people … read more

expert reaction to the Charlie Gard situation

Courts have ruled against continuing life-preserving treatment for 11 month old Charlie Gard. Since this ruling, offers of support and experimenyal treatment have come from both the US and Italy. read more

Expert reaction to study explaining technique behind first mitochondrial replacement therapy baby

Published in Reproductive Biomedicine Online, scientists have described the technique they used to create the first live birth after oocyte spindle transfer to prevent transmission of the mitochondrial disease, Leigh syndrome. read more

expert reaction to news that the HFEA has approved a licence application for Newcastle University to use mitochondrial donation therapy

The HFEA has approved a licence application for Newcastle University to use mitochondrial donation therapy in treating mitochondrial disease. read more

expert reaction to news of the birth of a baby in Ukraine through pronuclear transfer as a treatment for infertility

A baby has been born to a previously infertile couple in Ukraine using pronuclear transfer, a new type of “three-person IVF”. read more

expert reaction to HFEA decision to permit the clinical use of mitochondrial donation techniques in the UK

The HFEA decided to permit the clinical use of mitochondrial donation techniques in the UK. read more

expert reaction to study on mitochondrial replacement in human ooctyes that carry pathogenic mitochondrial dna mutations

Researchers, publishing in the journal Nature, have reported on a study which used mitochondrial donation therapy to replace pathogenic mitochondrial DNA mutations in human ooctyes with mitochondrial DNA from healthy donor eggs. The researchers report the potential of mitochondrial replacement therapy (MRT) to reduce the transfer of mitochondrial disease from mother to child. read more

expert reaction to fourth scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception

An independent expert panel, convened by the Human Fertilisation and Embryology Authority (HFEA), have published their fourth scientific review into the latest evidence on the safety and efficacy of mitochondrial donation techniques, recommending that those techniques be approved for “cautious use” in “specific circumstances”. These comments accompanied a press briefing. read more

report of fourth hfea independent science review panel on mitochondrial donation

After Parliament voted overwhelmingly in favour of allowing mitochondrial donation last year the UK regulatory process for this new treatment has moved on. The Newcastle based scientists ready to offer the treatment have answered more of the scientific questions raised and the HFEA commissioned a fourth independent science panel to review this and other research. Meanwhile stories emerge of babies being born around the world with the same technique but under very different regulatory oversight.

Now this incredible treatment takes a very significant step closer to the clinic as the science review panel delivers its fourth and possibly final report on the state of the science and makes recommendations as to whether it is safe and effective in order to proceed to treating patients.

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expert reaction to study describing the regeneration of functional human oocytes from discarded genetic material

Scientists publishing in the journal Cell Stem Cell have reported the production of functional human oocytes from discarded genetic material, a process which they suggest could one day assist in fertility treatment or mitochondrial replacement therapy. read more

expert reaction to reports of the first baby born (in Mexico) using the mitochondrial donation technique

A paper outline published online in the journal Fertility and Sterility and to be presented at the American Society for Reproductive Medicine conference in October reported what is thought to be the first baby born using mitochondrial donation techniques for the purpose of disease prevention. read more

expert reaction to a study looking at how mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

Publishing in Nature, scientists have reported that, in their study in mice, looking at mitochondrial donation, the matching of transferred mitochondrial DNA to nuclear DNA has an impact on metabolism and healthy ageing. read more

latest research on the safety and efficacy of mitochondrial donation therapy

A team from the Wellcome Trust Centre for Mitochondrial Donation presented results from their research into the safety of efficacy of the IVF-based technique known as mitochondrial donation. Mitochondrial donation involves transplanting the nuclear DNA of a recently formed embryo into an embryo which contains the mitochondrial DNA of a donor woman. The technique was designed to reduce the risk of mothers passing on mitochondrial disease, which is devastating and often life-limiting, to their children. A vote in the House of Commons in February 2015 made the technique legal in the UK but the first license has not yet been issued to a clinic. read more